Fig. 1 · Structure
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WS-383 free base
DCN1-UBC12 Inhibitor
WS-383 free base is a selective and reversible inhibitor of the DCN1-UBC12 interaction, exhibiting an IC50 of 11 nM. This compound effectively disrupts Cul3/1 neddylation, leading to the accumulation of key regulatory proteins including p21, p27, and NRF2. WS-383 free base serves as a valuable tool in research focused on protein neddylation and its implications in cellular regulation and disease mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2247543-65-1 |
| Applications | DCN1-UBC12 Inhibitor |
| Formula | C18H20ClN9S2 |
| Molecular Weight | 461.99 |
| SMILES | CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.