WWL0245 is a highly selective BRD4 PROTAC that effectively induces degradation of BRD4 with a sub-nanomolar DC50 of less than 1 nM, while demonstrating significantly lower potency against BRD2/3 and PLK1 (DC50 > 1 μM). This compound exhibits remarkable cytotoxicity in BET inhibitor-sensitive cancer cell lines, particularly in androgen receptor-positive prostate cancer models. WWL0245 serves as a valuable research tool for exploring the biological functions of BRD4 and holds potential as a therapeutic candidate in the context of AR-positive prostate cancer.
WWL0245 is a highly selective BRD4 PROTAC that effectively induces degradation of BRD4 with a sub-nanomolar DC50 of less than 1 nM, while demonstrating significantly lower potency against BRD2/3 and PLK1 (DC50 > 1 μM). This compound exhibits remarkable cytotoxicity in BET inhibitor-sensitive cancer cell lines, particularly in androgen receptor-positive prostate cancer models. WWL0245 serves as a valuable research tool for exploring the biological functions of BRD4 and holds potential as a therapeutic candidate in the context of AR-positive prostate cancer.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
