Fig. 1 · Structure
Documents & Downloads
WWL123 analogue-1
ABHD6 Inhibitor
WWL123 analogue-1 is a selective inhibitor of the serine hydrolase ABHD6, exhibiting an IC50 of 430 nM. This compound effectively crosses the blood-brain barrier, allowing it to inhibit ABHD6 within the central nervous system. Research has shown that blockade of ABHD6 by WWL123 analogue-1 may confer antiepileptic effects, demonstrated through reduction of seizures in both Pentylenetetrazole-induced models and spontaneous seizure models such as R6/2 mice. This makes it a valuable tool for studying neurological disorders and the role of lipid signaling in epilepsy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1338575-41-9 |
| Applications | ABHD6 Inhibitor |
| Formula | C28H24N2O3 |
| Molecular Weight | 436.50 |
| SMILES | O=C(C1=CC=C(C2=CC=CC(OC(N(CC3=CC=CC(C4=CC=CC=C4)=C3)C)=O)=C2)C=C1)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.