WYJ-2

Catalog No.: A35405
TLR2/1 Agonist
WYJ-2 is a selective agonist for toll-like receptor 2/1 (TLR2/1), exhibiting an EC50 of 18.57 nM in human TLR2 and TLR1 cotransfected HEK 293T cells. This compound induces pyroptosis, a form of programmed cell death, and demonstrates significant anticancer activity against non-small cell lung cancer (NSCLC). WYJ-2 is valuable for research in immunology and cancer therapy.
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionWYJ-2 is a selective agonist for toll-like receptor 2/1 (TLR2/1), exhibiting an EC50 of 18.57 nM in human TLR2 and TLR1 cotransfected HEK 293T cells. This compound induces pyroptosis, a form of programmed cell death, and demonstrates significant anticancer activity against non-small cell lung cancer (NSCLC). WYJ-2 is valuable for research in immunology and cancer therapy.
Product Information
Catalog NumA35405
FormulaC17H9F2N3O4
Molecular Weight357.27
CAS Number3029403-05-9
SMILESFC1=CC=C(C=C1C2=NC(C3=CC4=CC(F)=CC=C4OC3)=NO2)[N+]([O-])=O
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