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Xanthohumol I

Xanthohumol Derivative

Xanthohumol I is a chalcone derivative of Xanthohumol, known for its role as a Cholinesterase (ChE) inhibitor. It effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 71.34 μM and 32.67 μM, respectively. Additionally, its hydroxy derivative, 3-hydroxy-xanthohumol, also demonstrates inhibitory effects on AChE and BChE, with IC50 values of 51.25 μM and 63.07 μM. This compound is valuable for research in neurodegenerative diseases and related biochemical pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	688360-06-7
Applications	Xanthohumol Derivative
Formula	C₂₁H₂₂O₆
Molecular Weight	370.40
SMILES	OC1=CC=C(/C=C/C(C2=C3OC(C(C)(O)C)CC3=C(O)C=C2OC)=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.