Fig. 1 · Structure
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Xestospongin C
IP3R Inhibitor
Xestospongin C is a selective and reversible inhibitor of the inositol 1,4,5-trisphosphate receptor (IP3R), primarily targeting intracellular calcium signaling mechanisms. It effectively blocks IP3-induced calcium release from cerebellar microsomes with an IC50 of 358 nM, while also inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump. This compound serves as a critical tool for researchers studying the structure and function of IP3Rs, as well as elucidating calcium signaling pathways in both neuronal and nonneuronal cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 88903-69-9 |
| Applications | IP3R Inhibitor |
| Formula | C28H50N2O2 |
| Molecular Weight | 446.71 |
| Synonyms | (-)-Xestospongin C |
| SMILES | [H][C@]1([C@](CCCCCC[C@@](CCN2CCC3)([H])O[C@@]2([H])[C@]3([H])CCCCCC4)([H])CCC5)N5CC[C@]4([H])O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.