Fig. 1 · Structure
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XL 188
USP7 Inhibitor
XL 188 is a potent and selective inhibitor of ubiquitin-specific protease 7 (USP7), demonstrating IC50 values of 90 nM for the full-length enzyme and 193 nM for its catalytic domain. This reagent effectively modulates USP7 activity, making it a valuable tool for cancer research and investigations into the role of deubiquitinating enzymes in tumor progression and therapeutic resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2305045-76-3 |
| Applications | USP7 Inhibitor |
| Formula | C32H42N6O4 |
| Molecular Weight | 574.71 |
| SMILES | O=C(NC1=CC(N=CN2CC3(O)CCN(C(C[C@H](C4=CC=CC=C4)C)=O)CC3)=C(C=C1)C2=O)CCN5CCN(C)CC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.