Fig. 1 · Structure
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XL-784 free base
MMP Inhibitor
XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMPs), demonstrating potent inhibition with IC50 values of approximately 1900 nM for MMP-1, 0.81 nM for MMP-2, 120 nM for MMP-3, 10.8 nM for MMP-8, 18 nM for MMP-9, and 0.56 nM for MMP-13. This compound is essential for exploring the roles of MMPs in various biological processes including tissue remodeling, wound healing, and cancer metastasis. XL-784 free base can therefore serve as a valuable tool in pharmacological studies and drug development targeting MMP-related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1356992-21-6 |
| Applications | MMP Inhibitor |
| Formula | C21H22ClF2N3O8S |
| Molecular Weight | 549.93 |
| SMILES | O=C(N1CC(C(NO)=O)N(S(=O)(C2=CC(F)=C(OC3=CC=C(Cl)C=C3)C(F)=C2)=O)CC1)OCCOC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.