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XL541

S1P1 Antagonist

XL541 is a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1P1), effectively inhibiting GDP-GTP exchange. This compound has been shown to induce significant surface hemorrhaging in tumors, highlighting its potential as a therapeutic agent. Additionally, XL541 demonstrates enhanced antitumor activity when used in combination with Paclitaxel, making it a valuable tool for research in breast and lung cancer therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1221878-06-3
Applications	S1P1 Antagonist
Formula	C₂₈H₂₅F₂N₅O₃
Molecular Weight	517.53
SMILES	FC1=CC=C(OC2=CC=C(NC([C@H]3N(C(CN4C=CN=N4)=O)C[C@H](CC5=CC=C(F)C=C5)C3)=O)C=C2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.