YB-3-17 is a bifunctional PROTAC molecule that targets the mechanistic target of rapamycin (mTOR) with an IC50 of 0.22 nM and induces degradation of G1 to S phase transition 1 gene (GSPT1) with a DC50 of 5 nM. This compound demonstrates significant antiproliferative effects in various glioblastoma cell lines, achieving nanomolar IC50 values. Additionally, YB-3-17 exhibits notable antitumor efficacy in preclinical mouse models, making it a valuable tool for studying mTOR inhibition and its implications in cancer therapy.
YB-3-17 is a bifunctional PROTAC molecule that targets the mechanistic target of rapamycin (mTOR) with an IC50 of 0.22 nM and induces degradation of G1 to S phase transition 1 gene (GSPT1) with a DC50 of 5 nM. This compound demonstrates significant antiproliferative effects in various glioblastoma cell lines, achieving nanomolar IC50 values. Additionally, YB-3-17 exhibits notable antitumor efficacy in preclinical mouse models, making it a valuable tool for studying mTOR inhibition and its implications in cancer therapy.
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