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YF704

SHP2 Allosteric Inhibitor

YF704 is a selective allosteric inhibitor of SHP2, exhibiting an IC50 of 0.25 μM. This compound demonstrates significant antiproliferative effects and induces apoptosis in various cancer cell lines. Additionally, YF704 effectively downregulates Erk1/2 and Akt phosphorylation levels, highlighting its potential utility in cancer research and therapeutic applications targeting SHP2-mediated signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2956716-97-3
Applications	SHP2 Allosteric Inhibitor
Formula	C₁₇H₂₀Cl₂N₄OS₂
Molecular Weight	431.40
SMILES	N[C@@H]1[C@H](C)OCC12CCN(CC2)C(S3)=NN=C3SC4=C(Cl)C(Cl)=CC=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.