Fig. 1 · Structure
Documents & Downloads
YH-53
3CLpro Inhibitor
YH-53 is a potent inhibitor of the 3CLpro protease, demonstrating Ki values of 6.3 nM and 34.7 nM against SARS-CoV-1 and SARS-CoV-2 3CLpro, respectively. This peptidomimetic compound features a unique benzothiazolyl ketone structure and effectively inhibits SARS-CoV-2 replication. YH-53 holds promise for applications in COVID-19 research, providing valuable insights into therapeutic strategies against coronavirus infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1471484-62-4 |
| Applications | 3CLpro Inhibitor |
| Formula | C30H33N5O5S |
| Molecular Weight | 575.68 |
| SMILES | COC1=C2C(NC(C(N[C@@H](CC(C)C)C(N[C@@H](C[C@H]3C(NCC3)=O)C(C4=NC5=CC=CC=C5S4)=O)=O)=O)=C2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.