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YM-49598 iodide

Neurokinin Receptor Antagonist

YM-49598 iodide is a tachykinin NK-1 receptor antagonist that effectively inhibits neurokinin signaling. This compound has demonstrated the ability to reduce drug-induced bladder contractions in rat models, exhibiting an IC50 value of 11 μg/kg. Its application extends to research focused on pain modulation, inflammation, and bladder dysfunction, making it a valuable tool in pharmacological studies related to neurokinin pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	476494-44-7
Applications	Neurokinin Receptor Antagonist
Formula	C₃₆H₄₅Cl₂IN₂O₂
Molecular Weight	735.57
SMILES	CC(C)OC1=CC(CC(N2CC(C3=CC=C(C(Cl)=C3)Cl)(CCC2)CC[N+]4(CCC(CC4)C5=CC=CC=C5)C)=O)=CC=C1.[I-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.