Yoda2 (KC289) functions as a Piezo1 agonist with an EC50 of 150 nM, facilitating calcium ion elevation and nitric oxide-dependent relaxation. This compound induces vasodilation in mouse arterial and cavernous tissues. Additionally, Yoda2 is implicated in inhibiting glucocorticoid-induced osteoclast formation and bone resorptive activity, effectively reversing glucocorticoid-mediated bone density loss and structural deterioration. Its applications extend to research in areas such as hypertension and osteoporosis.
Yoda2 (KC289) functions as a Piezo1 agonist with an EC50 of 150 nM, facilitating calcium ion elevation and nitric oxide-dependent relaxation. This compound induces vasodilation in mouse arterial and cavernous tissues. Additionally, Yoda2 is implicated in inhibiting glucocorticoid-induced osteoclast formation and bone resorptive activity, effectively reversing glucocorticoid-mediated bone density loss and structural deterioration. Its applications extend to research in areas such as hypertension and osteoporosis.
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