(Z)-S49076 hydrochloride is a potent inhibitor of MET and AXL, effectively disrupting their downstream signaling pathways. This compound demonstrates significant biological activity by inhibiting the proliferation and migration of tumor cells and suppressing tumor growth in xenograft models. Additionally, (Z)-S49076 hydrochloride addresses resistance mechanisms associated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in Erlotinib-resistant cell lines. It is a valuable tool for research in non-small cell lung cancer (NSCLC).
(Z)-S49076 hydrochloride is a potent inhibitor of MET and AXL, effectively disrupting their downstream signaling pathways. This compound demonstrates significant biological activity by inhibiting the proliferation and migration of tumor cells and suppressing tumor growth in xenograft models. Additionally, (Z)-S49076 hydrochloride addresses resistance mechanisms associated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in Erlotinib-resistant cell lines. It is a valuable tool for research in non-small cell lung cancer (NSCLC).
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