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Erlotinib

EGFR inhibitor

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Catalog No. A11416

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Erlotinib 5g A11416-5000
$200.00
Erlotinib 10g A11416-10000
$350.00
Erlotinib 20g A11416-20000
$600.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.

Erlotinib

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Publications citing Adooq Products
Erlotinib Citations (4)
  • Manabe A, .et al. Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells, J Cell Physiol, 2018, Nov 21 PMID: 30461012
  • Yui Takashina, .et al. Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells, Nutrients, 2018, Oct; 10(10): 1345 PMID: 30241394
  • Furukawa C, .et al. Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, J Cell Physiol, 2017, Oct;232(10):2841-2850 PMID: 27925186
  • Xiaoyu Yang, .et al. Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs, Free Radic Biol Med, 2016, Aug; 97: 342-350 PMID: 27368132

Chemical Information

Catalog Num A11416
Actions Inhibitor
M. Wt 393.443
Formula C22H23N3O4?
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 183321-74-6
Synonyms CP-358,774, CP-358774, CP358774, OSI-774, OSI 774, OSI774, Erlotinib free base.
SMILES COCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC

Biological Activity

Description
Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.42 mL 127.08 mL 254.17mL
0.5 mM 5.08 mL 25.42 mL 50.83 mL
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.443. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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