Fig. 1 · Structure
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(Z)-Semaxanib
Tyrosine Kinase Inhibitor
(Z)-Semaxanib is a potent tyrosine kinase inhibitor that demonstrates significant cytotoxicity against TAMH and HepG2 cancer cell lines, with IC50 values of 6.28 µM and 8.17 µM, respectively. This compound is utilized in research applications focused on cancer treatment, specifically in studies targeting signaling pathways involved in tumor growth and progression. Its efficacy in inhibiting tyrosine kinases makes (Z)-Semaxanib a valuable tool for exploring therapeutic strategies in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 194413-58-6 |
| Applications | Tyrosine Kinase Inhibitor |
| Formula | C15H14N2O |
| Molecular Weight | 238.29 |
| Synonyms | (Z)-SU5416 |
| SMILES | O=C(NC1=C/2C=CC=C1)C2=C/C3=C(C)C=C(C)N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.