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Z1609609733

PHGDH Inhibitor

Z1609609733 is a non-covalent inhibitor of 3-Phosphoglycerate dehydrogenase (PHGDH), exhibiting an IC50 of 1.46 μM. This compound effectively disrupts serine synthesis and alters cancer metabolism, leading to significant inhibition of cell proliferation. It is valuable for research into metabolic pathways and therapeutic strategies targeting serine biosynthesis in cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2375374-15-3
Applications	PHGDH Inhibitor
Formula	C₃₀H₂₇Cl₂N₃O₆
Molecular Weight	596.46
SMILES	O=C(OC(OC(C)=O)C)C(C1=CC=C(C2(NC(C(N3C)=CC4=C3C=CC(Cl)=C4Cl)=O)COC2)C=C1)C5=CC=CN=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.