Fig. 1 · Structure

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ZA18

Cat. No. A68830 CAS 2696407-32-4

TRPM2 Channel Inhibitor

ZA18 is a selective inhibitor of the TRPM2 channel, characterized by an IC50 value of 6.2 μM. This compound effectively mitigates intracellular calcium overload caused by TRPM2 activation and significantly decreases the mortality of SH-SY5Y cells subjected to H2O2-induced stress. ZA18 is suitable for investigating mechanisms underlying ischemia-reperfusion injury, inflammation, and various neurodegenerative diseases.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2696407-32-4
Applications TRPM2 Channel Inhibitor
Formula C29H30N4O
Molecular Weight 450.57
SMILES
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)C3=C(C)N=C4N(CCN(CC)CC)C5=CC=CC=C5N43

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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