Zanapezil free base is a potent, reversible, and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant AChE activity inhibition in homogenates of the rat cerebral cortex, with an IC50 value of 51.2 nM. Additionally, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding, with Ki values of 234 nM and 340 nM, respectively. This compound is suitable for research focused on the early stages of Alzheimer's disease, contributing to the understanding of cholinergic dysfunction in neurodegenerative disorders.
Zanapezil free base is a potent, reversible, and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant AChE activity inhibition in homogenates of the rat cerebral cortex, with an IC50 value of 51.2 nM. Additionally, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding, with Ki values of 234 nM and 340 nM, respectively. This compound is suitable for research focused on the early stages of Alzheimer's disease, contributing to the understanding of cholinergic dysfunction in neurodegenerative disorders.
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