Fig. 1 · Structure

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Zaptuzumab

DR5 Monoclonal Antibody

Zaptuzumab is a humanized monoclonal antibody targeting DR5 with high specificity and affinity. This compound effectively induces apoptosis in cancer cells through caspase activation and autophagic cell death, while also promoting antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Additionally, Zaptuzumab disrupts redox homeostasis by generating reactive oxygen species (ROS) and decreasing glutathione levels. It has demonstrated significant tumor growth suppression and favorable safety profiles in various xenograft mouse models, making it a valuable tool in cancer research.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 2378046-35-4
Applications DR5 Monoclonal Antibody
Synonyms AD5-10

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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