Zaragozic acid A is a reversible competitive inhibitor of squalene synthase, acting as an endogenous metabolite. This compound effectively inhibits acute hepatic cholesterol synthesis in mouse models, with an IC50 value of 6 μM. Its application is significant in studies investigating cholesterol metabolism and the regulation of lipid biosynthesis.
Zaragozic acid A is a reversible competitive inhibitor of squalene synthase, acting as an endogenous metabolite. This compound effectively inhibits acute hepatic cholesterol synthesis in mouse models, with an IC50 value of 6 μM. Its application is significant in studies investigating cholesterol metabolism and the regulation of lipid biosynthesis.
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