Fig. 1 · Structure
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Zidovudine O-β-D-glucuronide sodium
Zidovudine Metabolite
Zidovudine O-β-D-glucuronide sodium is the principal metabolite of Zidovudine, a nucleoside reverse transcriptase inhibitor (NRTI) utilized in HIV treatment. This compound serves as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it valuable for various molecular applications in chemical biology and pharmacokinetics research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 133525-01-6 |
| Applications | Zidovudine Metabolite |
| Formula | C16H20N5NaO10 |
| Molecular Weight | 465.35 |
| Synonyms | 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium |
| SMILES | O=C(NC1=O)N(C=C1C)[C@](C[C@@H]2N=[N+]=[N-])([H])O[C@@H]2CO[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)C(O[Na])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.