ZLD10A is a potent and selective inhibitor of the histone methyltransferase EZH2, effectively blocking H3K27 methylation. Demonstrating nanomolar potency against both wild-type and mutant forms of EZH2, ZLD10A exhibits over 1000-fold selectivity compared to other histone methyltransferases. Its ability to inhibit cell proliferation in diffuse large B-cell lymphoma (DLBCL) cell lines in a concentration- and time-dependent manner highlights its potential as an antiproliferative agent. ZLD10A serves as a valuable tool for investigating EZH2 mutant lymphomas.
ZLD10A is a potent and selective inhibitor of the histone methyltransferase EZH2, effectively blocking H3K27 methylation. Demonstrating nanomolar potency against both wild-type and mutant forms of EZH2, ZLD10A exhibits over 1000-fold selectivity compared to other histone methyltransferases. Its ability to inhibit cell proliferation in diffuse large B-cell lymphoma (DLBCL) cell lines in a concentration- and time-dependent manner highlights its potential as an antiproliferative agent. ZLD10A serves as a valuable tool for investigating EZH2 mutant lymphomas.
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