PRMT5-MTA-IN-4 is a potent irreversible inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating an IC50 of 8 nM. This compound effectively blocks arginine methylation, leading to the inhibition of ribosomal RNA processing and the expression of cell cycle-related proteins. PRMT5-MTA-IN-4 exhibits significant antiproliferative effects across various tumor cell lines, with an IC50 of 0.3 μM in DLD-1 cells. This reagent is an important tool for investigating hematological malignancies, including acute myeloid leukemia and diffuse large B-cell lymphoma.
PRMT5-MTA-IN-4 is a potent irreversible inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating an IC50 of 8 nM. This compound effectively blocks arginine methylation, leading to the inhibition of ribosomal RNA processing and the expression of cell cycle-related proteins. PRMT5-MTA-IN-4 exhibits significant antiproliferative effects across various tumor cell lines, with an IC50 of 0.3 μM in DLD-1 cells. This reagent is an important tool for investigating hematological malignancies, including acute myeloid leukemia and diffuse large B-cell lymphoma.
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