ZM 253270 is a non-peptide antagonist targeting the neurokinin-2 receptor (NK-2R). It competitively inhibits the binding of [3H]NKA to native or cloned hamster NK-2R, demonstrating high potency with a Ki value of 2 nM. In contrast, ZM 253270 exhibits reduced efficacy on cloned human NK-2R, with a 48-fold weaker inhibitory effect. This compound is valuable for research investigating the role of NK-2R in various physiological and pathological processes.
ZM 253270 is a non-peptide antagonist targeting the neurokinin-2 receptor (NK-2R). It competitively inhibits the binding of [3H]NKA to native or cloned hamster NK-2R, demonstrating high potency with a Ki value of 2 nM. In contrast, ZM 253270 exhibits reduced efficacy on cloned human NK-2R, with a 48-fold weaker inhibitory effect. This compound is valuable for research investigating the role of NK-2R in various physiological and pathological processes.
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