ZM-32 is a potent inhibitor of human antigen R (HuR), a critical regulator of mRNA stability. By downregulating the expression of vascular endothelial growth factor A (VEGF-A) and matrix metalloproteinase 9 (MMP9), ZM-32 effectively inhibits angiogenesis in breast cancer. Demonstrating broad-spectrum anti-proliferative effects across various cancer cell lines, ZM-32 also shows significant antitumor efficacy in mouse models of the MDA-MB-231 breast cancer cell line.
ZM-32 is a potent inhibitor of human antigen R (HuR), a critical regulator of mRNA stability. By downregulating the expression of vascular endothelial growth factor A (VEGF-A) and matrix metalloproteinase 9 (MMP9), ZM-32 effectively inhibits angiogenesis in breast cancer. Demonstrating broad-spectrum anti-proliferative effects across various cancer cell lines, ZM-32 also shows significant antitumor efficacy in mouse models of the MDA-MB-231 breast cancer cell line.
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