Fig. 1 · Structure
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Zoniporide hydrochloride hydrate
NHE-1 Inhibitor
Zoniporide hydrochloride hydrate is a selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1), demonstrating a potent inhibitory effect on human NHE-1 with an IC50 of 14 nM and over 150-fold selectivity against other NHE isoforms. This compound effectively inhibits NHE-1-dependent swelling of human platelets with an IC50 of 59 nM. Zoniporide hydrochloride hydrate is valuable for research applications targeting cardiovascular diseases and cellular processes involving pH regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 863406-85-3 |
| Applications | NHE-1 Inhibitor |
| Formula | C17H19ClN6O2 |
| Molecular Weight | 374.82 |
| Synonyms | CP-597396 hydrochloride hydrate |
| SMILES | O=C(C1=C(C2CC2)N(C3=C4C=CC=NC4=CC=C3)N=C1)NC(N)=N.[H]Cl.[H]O[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.