Fig. 1 · Structure
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Zunsemetinib
MK2 Pathway Inhibitor
Zunsemetinib is an orally active and selective inhibitor of the p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway. This compound demonstrates significant efficacy in modulating inflammatory responses, making it a valuable tool for the investigation of immuno-inflammatory diseases. Its specificity towards the MK2 pathway allows for a targeted approach in research applications aimed at understanding disease mechanisms and developing potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1640282-42-3 |
| Applications | MK2 Pathway Inhibitor |
| Formula | C25H22ClF2N5O3 |
| Molecular Weight | 513.92 |
| Synonyms | ATI-450; CDD-450 |
| SMILES | FC1=CC(F)=CN=C1COC2=C(Cl)C(N(C3=CC(C4=NC(C(C)(C)O)=NC=C4)=NC=C3C)C(C)=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.