Target & Activity
| Target | Activity | Value |
|---|---|---|
| HDAC3 | 0.57 μM | |
| HDAC2 | 1.12 μM | |
| HDAC1 | 1.20 μM |
Fig. 1 · Structure
Documents & Downloads
Domatinostat (4SC-202)
Cat. No.
A14354
CAS
910462-43-0
HDAC inhibitor
4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 910462-43-0 |
| Applications | HDAC inhibitor |
| Formula | C23H21N5O3S |
| Molecular Weight | 447.51 |
| Synonyms | 4SC-202 |
| SMILES | CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)/C=C/C(=O)NC4=CC=CC=C4N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 77 mg/mL (172.06 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 9 mg/mL
- Vehicle
- 2% DMSO+30% PEG 300+5% Tween 80+ddH2O
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.