AP24534 (Ponatinib)

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BCR-ABL inhibitor

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Catalog No. A10080

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AP24534 10mg A10080-10

Regular Price: $40.00

Special Price: $34.00

AP24534 25mg A10080-25

Regular Price: $50.00

Special Price: $42.50

AP24534 50mg A10080-50

Regular Price: $75.00

Special Price: $63.75

AP24534 100mg A10080-100

Regular Price: $100.00

Special Price: $85.00

AP24534 (Ponatinib) 10mM * 1mL in DMSO A10080-10mM-D

Regular Price: $80.00

Special Price: $68.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.

AP24534 (Ponatinib)

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Chemical Information

Catalog Num A10080
Actions Inhibitor
M. Wt 532.6
Formula C29H27F3N6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 943319-70-8
Synonyms Ponatinib
SMILES code CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Chemical Name 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide

Biological Activity

Description
AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.
Targets
Target Value
AblIC50: 0.37nM
PDGFRαIC50: 1.1nM
VEGFR2IC50: 1.5nM
FGFR1IC50: 2.2nM
c-SrcIC50: 5.4nM
c-KitIC50: 12.5nM
Insulin ReceptorIC50: >1μM
IGF-1RIC50: >1μM
AuroraAIC50: >1μM
CDK2/CyclinEIC50: >1μM

Solubility

Solubility (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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