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Fig. 1 · Structure
Cat. No.
A11361
CAS No.
926259-99-6
Formula
C11H10N4O
Mol. Weight
214.22

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BG45

Cat. No. A11361 CAS 926259-99-6

HDAC inhibitor

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).

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Biological Activity

Target & Activity

Target Activity Value
HDAC3 289 nM
HDAC1 2 μM
HDAC2 2.2 μM
HDAC6 >20 μM

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 29.14 μM Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay [PMID: 31420269]
B16-F10 IC50 34.59 μM Antiproliferative activity against mouse B16F10 cells incubated for 48 hrs by MTT assay [PMID: 31420269]
HeLa IC50 28.28 μM Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay [PMID: 31420269]
Sf9 IC50 > 20000 nM Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 insect cells using (S)-6-acetamido-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide as substrate by fluorescence assa [PMID: 30735902]
Sf9 IC50 2000 nM Inhibition of recombinant human full length C-terminal His/FALG-tagged HDAC1 expressed in Sf9 insect cells using (S)-6-acetamido-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide as substrate by fluorescence [PMID: 30735902]
Sf9 IC50 2200 nM Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC2 expressed in Sf9 insect cells using (S)-6-acetamido-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide as substrate by fluorescence ass [PMID: 30735902]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 926259-99-6
Applications HDAC inhibitor
Formula C11H10N4O
Molecular Weight 214.22
SMILES
Nc1ccccc1NC(=O)c1cnccn1

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 40 mg/mL (186.72 mM)
Water Insoluble
Ethanol Warmed: 2 mg/mL (9.33 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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