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Fig. 1 · Structure
Cat. No.
A11964
CAS No.
112522-64-2
Formula
C15H15N3O2
Mol. Weight
269.3

Documents & Downloads

Tacedinaline (CI994)

Cat. No. A11964 CAS 112522-64-2

HDAC Inhibitor

CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells.

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Biological Activity

Target & Activity

Target Activity Value
HDAC1 (Cell-free assay) 0.9 μM
HDAC2 0.9 μM
HDAC3 1.2 μM

Cellular Effect

Cell Line Activity Value Description Reference
A-375 IC50 11.29 μM Antiproliferative activity against human A375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay [PMID: 31003060]
A-375 IC50 11.29 μM Antiproliferative activity against human A375 cells after 72 hrs by CCK-8 assay [PMID: 29202397]
A-375 IC50 11.3 μM Antiproliferative activity against human A375 cells after 72 hrs CCK8 assay [PMID: 30108928]
A-375 IC50 9.64 μM Antiproliferative activity against human A375 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay [PMID: 31103900]
A549 IC50 10.17 μM Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay [PMID: 30045621]
A549 IC50 15.96 μM Cytotoxicity against human A549 cells assessed as decrease in cell viability measured after 72 hrs by CellTiter-Glo Luminescent assay [PMID: 31223439]
A549 IC50 16.45 μM Antiproliferative activity against human A549 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay [PMID: 31103900]
A549 IC50 20.1 μM Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay [PMID: 31003060]
A549 IC50 20.1 μM Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 reagent based assay [PMID: 28391133]
A549 IC50 20.1 μM Antiproliferative activity against human A549 cells after 72 hrs CCK8 assay [PMID: 30108928]
Epithelial cell IC50 > 50 μM Cytotoxicity against human mammary epithelial cells by MTT assay [PMID: 17941625]
HCT-116 IC50 10 μM Cytotoxicity in human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay [PMID: 28885834]
HCT-116 IC50 4 μM Cytotoxicity against human HCT116 cells by MTT assay [PMID: 17941625]
HCT-116 IC50 6.39 μM Antiproliferative activity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay [PMID: 31103900]
HCT-116 IC50 7.71 μM Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay [PMID: 31003060]
HCT-116 IC50 7.71 μM Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay [PMID: 29202397]
HCT-116 IC50 7.71 μM Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 reagent based assay [PMID: 28391133]
HCT-116 EC50 8.4 μM Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by cell-titer glo assay [PMID: 35293758]
HCT-116 IC50 9.83 μM Antiproliferative activity against human HCT116 cells after 72 hrs by CCK8 assay [PMID: 30045621]
HeLa IC50 1.81 μM Inhibition of HDAC in human HeLa cell nuclear extract assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay [PMID: 31103900]

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 112522-64-2
Applications HDAC Inhibitor
Formula C15H15N3O2
Molecular Weight 269.3
Synonyms CI-994; Acetyldinaline; Goe 5549; G? 5549. PD 123654
SMILES
CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 51 mg/mL (189.37 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration
4 mg/mL
Vehicle
5% DMSO+40% PEG 300+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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