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Fig. 1 · Structure
Cat. No.
A12736
CAS No.
177355-84-9
Formula
C22H20N4
Mol. Weight
340.42

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DBeQ

Cat. No. A12736 CAS 177355-84-9

p97 ATPase inhibitor

Dbeq is a selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 uM).

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Biological Activity

Target & Activity

Target Activity Value
p97 1.5 μM

Cellular Effect

Cell Line Activity Value Description Reference
HT-29 IC50 4.72 μM Cytotoxicity against human HT-29 cells after 72 hrs by neutral red dye assay [PMID: 21700369]
HT-29 IC50 4.72 μM Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based spectrophotometric analysis [PMID: 35694693]
J774.A1 EC50 0.67 μM Antileishmanial activity against intracellular amastigote stage of Leishmania donovani MHOM/ET/67/L82 infected in mouse J774A1 cells by colorimetric assay [PMID: 24874647]
J774.A1 EC50 1.4 μM Antileishmanial activity against intracellular amastigote stage of Leishmania amazonensis LV78 infected in mouse J774A1 cells by colorimetric assay [PMID: 24874647]
J774.A1 EC50 5.5 μM Cytotoxicity against mouse J774A.1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay [PMID: 25749014]
J774.A1 EC50 5.5 μM Cytotoxicity against mouse J774A1 cells after 72 hrs by MTT assay [PMID: 24874647]
MDA-MB-231 IC50 1.79 μM Cytotoxicity against human MDA-MB-231 cells after 72 hrs by neutral red dye assay [PMID: 21700369]
MDA-MB-231 IC50 1.79 μM Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based spectrophotometric analysis [PMID: 35694693]
T-24 IC50 5.96 μM Cytotoxicity against human T24 cells after 72 hrs by neutral red dye assay [PMID: 21700369]
T-24 IC50 5.96 μM Antiproliferative activity against human T24 cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based spectrophotometric analysis [PMID: 35694693]

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 177355-84-9
Applications p97 ATPase inhibitor
Formula C22H20N4
Molecular Weight 340.42
SMILES
C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 65 mg/mL (190.94 mM)
Water Insoluble
Ethanol 5 mg/mL (14.68 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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