EMD-1214063 ON SALE c-Met Inhibitor

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Catalog No. A11257

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
EMD-1214063 5mg A11257-5

Regular Price: $110.00

Special Price: $93.50

EMD-1214063 10mg A11257-10

Regular Price: $200.00

Special Price: $170.00

EMD-1214063 50mg A11257-50

Regular Price: $580.00

Special Price: $493.00

EMD-1214063 100mg A11257-100

Regular Price: $980.00

Special Price: $833.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. It binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.

EMD-1214063

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Chemical Information

Catalog Num A11257
Actions Inhibitor
M. Wt 492.6
Formula C29H28N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1100598-32-0
Synonyms EMD1214063
SMILES code CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC(=CC=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N
Chemical Name 3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile

Biological Activity

Description
EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. It binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.
Targets
Target Value
c-MetIC50: 4nM
IRAK4IC50: 615nM
TrkAIC50: 1.017μM
AxlIC50: 1.566μM
IRAK1IC50: 2.037μM
MerIC50: 2.272μM
TrkBIC50: 5.716μM
RONIC50: >10μM

Solubility

Solubility (25°C)* In vitro DMSO 5 mg/mL heating (10.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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