E-7050 (Golvatinib)

Name: E-7050 (Golvatinib)
SKU: A11396

Catalog No.: A11396

E-7050 (Golvatinib)

E-7050 (Golvatinib) Chemical Structure

CAS NO. 928037-13-2

E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity.

Availability: In stock

Package	Price	Qty
10 mg	Regular Price: $110.00 Special Price $88.00
25 mg	Regular Price: $220.00 Special Price $176.00
50 mg	Regular Price: $380.00 Special Price $304.00
100 mg	Regular Price: $680.00 Special Price $544.00
10mM * 1mL in DMSO	$129.00

Price Match Request

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Nature 2017
551, 247-250

Science
2017; 356(6336)

Nat Chem Biol.
1, 713–720 (2015)

Nat Commun
2016; 7: 11051.

Nat Cell Biol. 2013
15(12):1473-85.

Cell 2014 Feb 27
156(5):986-1001.

Nat Commun
2015; 6: 7139.

PNAS 2014
111(43) 15514-15519

PNAS 2014
111(23) E2404-E2413

J Neurosci. 2015
35(5): 2101–2111

Scientific Reports
5, 12298.

Cell Research
225, 707–725.

Oncogene
2014, 1–14 .

Details

Biological Activity

Targets

c-Met	VEGFR2
14 nM	16 nM

Solubility *

In vitro (25°C)	DMSO	20 mg/mL (31.56 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	<1 mg/mL (<1 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	30 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.78 mL	78.9 mL	157.81 mL
0.5 mM	3.16 mL	15.78 mL	31.56 mL
1 mM	1.58 mL	7.89 mL	15.78 mL
5 mM	0.32 mL	1.58 mL	3.16 mL

*The above data is based on the productmolecular weight 633.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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VEGFR2

c-Met

Technical Details

Catalog Num	A11396
Actions	N/A
M. Wt	633.69
Formula	C33H37F2N7O4
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	928037-13-2
Synonyms	N/A
SMILES	CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F