GSK2656157

PERK Inhibitor

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Catalog No. A13577

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GSK2656157 10mg A13577-10
$70.00
GSK2656157 25mg A13577-25
$150.00
GSK2656157 50mg A13577-50
$250.00
GSK2656157 100mg A13577-100
$400.00
GSK2656157 10mM * 1mL in DMSO A13577-10mM-D
$75.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.

GSK2656157

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Chemical Information

Catalog Num A13577
Actions Inhibitor
M. Wt 416.45
Formula C23H21FN6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1337532-29-2
Synonyms GSK 2656157
SMILES code CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C
Chemical Name 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone

Biological Activity

Description
GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
Targets
PERK (Cell-free assay)
0.9 nM

Solubility

Solubility (25°C)* In vitro DMSO 32 mg/mL (76.83 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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