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Histone Deacetylase (HDAC)

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  • ACY-1215 (Rocilinostat)

    A11940 ACY-1215 (Rocilinostat)

    ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
  • AR-42 (HDAC-42)

    A11037 AR-42 (HDAC-42)

    AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
  • Belinostat (PXD101)

    A10122 Belinostat (PXD101)

    Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM.
  • Carbamazepine

    A10179 Carbamazepine

    Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia.
  • CI994 (Tacedinaline)

    A11964 CI994 (Tacedinaline)

    CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells.
  • CUDC-101

    A10246 CUDC-101

    CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.
  • CUDC-907

    A11153 CUDC-907

    CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
  • Droxinostat

    A10337 Droxinostat

    Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively.
  • ITF2357 (Givinostat)

    A10488 ITF2357 (Givinostat)

    ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
  • JNJ-26481585

    A10492 JNJ-26481585

    JNJ-26481585 is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L).

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