AR-42 (HDAC-42)

Catalog No.: A11037

HDAC inhibitor

AR-42 (HDAC-42)

AR-42 (HDAC-42) Chemical Structure

CAS NO. 935881-37-1

AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$150.00
25 mg
$300.00
50 mg
$550.00
10mM * 1mL in DMSO
$109.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yong-Hui Liao, .et al. Histone deacetylase 2 is involved in μ-opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain, Mol Med Rep, 2018, Feb; 17(2): 2803-2810 PMID: 29257262

Biological Activity

AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
Targets
HDAC
30 nM
In vitro (25°C) DMSO 62 mg/mL (198.49 mM)
Water Insoluble
Ethanol 62 mg/mL (198.49 mM)
In vivo 0.5% methylcellulose+0.2% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.01 mL 160.05 mL 320.1 mL
0.5 mM 6.4 mL 32.01 mL 64.02 mL
1 mM 3.2 mL 16.01 mL 32.01 mL
5 mM 0.64 mL 3.2 mL 6.4 mL

*The above data is based on the productmolecular weight 312.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11037
Actions Inhibitor
CAS No. 935881-37-1
Formula C18H20N2O3
M. Wt 312.4
Purity >98%
Synonyms AR42, OSU-HDAC42
SMILES CC(C)[[email protected]@H](C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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