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- Elena Netchiporouk, .et al. Analysis of CTCL cell lines reveals important differences between mycosis fungoides/S谷zary syndrome vs. HTLV-1+ leukemic cell lines, Oncotarget, 2017, Nov 10; 8(56): 95981每95998 PMID: 29221181
- Ivan V. Litvinov, .et al. Ectopic expression of cancer testis antigens in Cutaneous T-Cell Lymphoma (CTCL) patients, Clin Cancer Res., 2014, 20(14): 3799每3808. PMID: 24850846
- Ivan V Litvinov, .et al. Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines, Cell Cycle., 2014, 15; 13(18): 2975每2982. PMID: 25486484
|Storage||at -20°C 3 years Powder|
|Synonyms||FK228, FR9N/A1228, depsipeptide, NSC 63N/A176)|
|SMILES||C/C=C\1/C(=O)N[[email protected]](C(=O)O[[email protected]]\2CC(=O)N[[email protected]@H](C(=O)N[[email protected]](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C|
|Chemical Name||Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5)-disulfide|
|Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively.|
|Solubility (25°C) *||In vitro||DMSO||10 mg/mL (18.49 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||1% DMSO/30% polyethylene glycol/1% Tween 80||18 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||18.49 mL||92.47 mL||184.95mL|
|0.5 mM||3.7 mL||18.49 mL||36.99 mL|
|1 mM||1.85 mL||9.25 mL||18.49 mL|
|5 mM||0.37 mL||1.85 mL||3.7 mL|
*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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