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Romidepsin (FK228 ,Depsipeptide)


HDAC inhibitor

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Catalog No. A11920

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Romidepsin (FK228 ,Depsipeptide) 1mg A11920-1

Regular Price: €95.00

Special Price: €85.50

Romidepsin (FK228 ,Depsipeptide) 2mg A11920-2

Regular Price: €152.00

Special Price: €136.80

Romidepsin (FK228 ,Depsipeptide) 5mg A11920-5

Regular Price: €304.00

Special Price: €273.60

Romidepsin (FK228 ,Depsipeptide) 10mg A11920-10

Regular Price: €475.00

Special Price: €427.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively.

Romidepsin (FK228 ,Depsipeptide)

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Publications citing Adooq Products
Romidepsin (FK228 ,Depsipeptide) Citations (3)
  • Elena Netchiporouk, .et al. Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sézary syndrome vs. HTLV-1+ leukemic cell lines, Oncotarget, 2017, Nov 10; 8(56): 95981-95998 PMID: 29221181
  • Ivan V. Litvinov, .et al. Ectopic expression of cancer testis antigens in Cutaneous T-Cell Lymphoma (CTCL) patients, Clin Cancer Res., 2014, 20(14): 3799-3808. PMID: 24850846
  • Ivan V Litvinov, .et al. Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines, Cell Cycle., 2014, 15; 13(18): 2975-2982. PMID: 25486484

Chemical Information

Catalog Num A11920
Actions Inhibitor
M. Wt 540.7
Formula C24H36N4O6S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 128517-07-7
Synonyms FK228, FR9N/A1228, depsipeptide, NSC 63N/A176)
SMILES C/C=C\1/C(=O)N[[email protected]](C(=O)O[[email protected]]\2CC(=O)N[[email protected]@H](C(=O)N[[email protected]](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C

Biological Activity

Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively.
HDAC1 (Cell-free assay) HDAC2 (Cell-free assay)
36 nM47 nM


Solubility (25°C) * In vitro DMSO 10 mg/mL (18.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.49 mL 92.47 mL 184.95mL
0.5 mM 3.7 mL 18.49 mL 36.99 mL
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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