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Publications citing Adooq Products
Romidepsin (FK228 ,Depsipeptide) Citations (3)
- Elena Netchiporouk,et al. Analysis of CTCL cell lines reveals important differences between mycosis fungoides/S谷zary syndrome vs. HTLV-1+ leukemic cell lines, Oncotarget, 2017, Nov 10; 8(56): 95981-95998 29221181
- Ivan V. Litvinov,et al. Ectopic expression of cancer testis antigens in Cutaneous T-Cell Lymphoma (CTCL) patients, Clin Cancer Res., 2014, 20(14): 3799-3808. 24850846
- Ivan V Litvinov,et al. Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines, Cell Cycle., 2014, 15; 13(18): 2975-2982. 25486484
Chemical Information
| Catalog Num | A11920 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 540.7 |
| Formula | C24H36N4O6S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 128517-07-7 |
| Synonyms | FK228, FR9N/A1228, depsipeptide, NSC 63N/A176) |
| SMILES code | C/C=C\1/C(=O)N[[email protected]](C(=O)O[[email protected]]\2CC(=O)N[[email protected]@H](C(=O)N[[email protected]](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C |
| Chemical Name | Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5)-disulfide |
Description |
Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C) * | In vitro | DMSO | 10 mg/mL (18.49 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 18 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.49 mL | 92.47 mL | 184.95mL |
| 0.5 mM | 3.7 mL | 18.49 mL | 36.99 mL |
| 1 mM | 1.85 mL | 9.25 mL | 18.49 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.7 mL |
*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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