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- Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
Biological Activity
Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM.
Targets
| HDAC (Cell-free assay) | ||||
| 27 nM |
| In vitro (25°C) | DMSO | 56 mg/mL (175.9 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.41 mL | 157.04 mL | 314.07 mL |
| 0.5 mM | 6.28 mL | 31.41 mL | 62.81 mL |
| 1 mM | 3.14 mL | 15.7 mL | 31.41 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
*The above data is based on the productmolecular weight 318.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10122 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 414864-00-9 |
| Formula | C15H14N2O4S |
| M. Wt | 318.4 |
| Purity | >98% |
| Synonyms | PX105684 |
| SMILES | C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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