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RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3.
Targets
| HDAC3 (Cell-free assay) | HDAC1 (Cell-free assay) | HDAC3 (Cell-free assay) | HDAC1 (Cell-free assay) | |
| 5 nM(Ki) | 32 nM(Ki) | 5 nM(Ki) | 32 nM(Ki) |
| In vitro | DMSO | 68 mg/mL (200.33 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 10 mg/mL (29.46 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.46 mL | 147.31 mL | 294.61 mL |
| 0.5 mM | 5.89 mL | 29.46 mL | 58.92 mL |
| 1 mM | 2.95 mL | 14.73 mL | 29.46 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.89 mL |
*The above data is based on the productmolecular weight 339.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A13139 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 339.43 |
| Formula | C20H25N3O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1215493-56-3 |
| Synonyms | RGFP109 |
| SMILES | CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N |
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