ITF2357 (Givinostat)

Catalog No.: A10488

HDAC inhibitor

ITF2357 (Givinostat)

ITF2357 (Givinostat) Chemical Structure

CAS NO. 732302-99-7

ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$450.00
100 mg
$750.00
10mM * 1mL in DMSO
$145.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
Targets
HD1-B (Cell-free assay) HD2 (Cell-free assay) HD1-A (Cell-free assay)
7.5 nM10 nM16 nM
In vitro (25°C) DMSO 95 mg/mL (199.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.3 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.01 mL 105.04 mL 210.08 mL
0.5 mM 4.2 mL 21.01 mL 42.02 mL
1 mM 2.1 mL 10.5 mL 21.01 mL
5 mM 0.42 mL 2.1 mL 4.2 mL

*The above data is based on the productmolecular weight 476.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10488
Actions Inhibitor
M. Wt 476.0
Formula C24H27N3O4.HCl.H2O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 732302-99-7
Synonyms Gavinostat
SMILES CC[NH+](CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.[Cl-]

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