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ITF2357 (Givinostat)

Catalog No.: A10488

HDAC inhibitor

ITF2357 (Givinostat)

ITF2357 (Givinostat) Chemical Structure

CAS NO. 732302-99-7

ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
HD1-B (Cell-free assay) HD2 (Cell-free assay) HD1-A (Cell-free assay)
7.5 nM10 nM16 nM
In vitro (25°C) DMSO 94 mg/mL (197.49 mM)
Water Insoluble
Ethanol 3 mg/mL
In vivo 5%DMSO+40%PEG300++5%Tween80+50%ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.01 mL 105.04 mL 210.08 mL
0.5 mM 4.2 mL 21.01 mL 42.02 mL
1 mM 2.1 mL 10.5 mL 21.01 mL
5 mM 0.42 mL 2.1 mL 4.2 mL

*The above data is based on the productmolecular weight 476.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10488
Actions Inhibitor
CAS No. 732302-99-7
Formula C24H27N3O4.HCl.H2O
M. Wt 476.0
Purity >98%
Synonyms Gavinostat

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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