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LBH589 (Panobinostat)

Catalog No.: A10518

HDAC Inhibitor

LBH589 (Panobinostat)

LBH589 (Panobinostat) Chemical Structure

CAS NO. 404950-80-7

LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.

Availability: In stock

Package Price Qty
10 mg
50 mg
100 mg
200 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Jalila Chagraoui, .et al. UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
  • Gils Jose, .et al. Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy, Cancers (Basel), 2020, Oct 31;12(11):E3211 PMID: 33142721
  • Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
  • Giovanni Bocci, .et al. Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, ACS Pharmacol Transl Sci, 2020, Oct 14
  • Justin Kale, .et al. Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance, EMBO Rep, 2018, Sep; 19(9): e45235 PMID: 29987135

Biological Activity

LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
HDAC (MOLT-4 cells) HDAC (Reh cells)
5 nM20 nM
In vitro (25°C) DMSO 60 mg/mL (171.7 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+48% PEG 300+2% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.62 mL 143.1 mL 286.2 mL
0.5 mM 5.72 mL 28.62 mL 57.24 mL
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL

*The above data is based on the productmolecular weight 349.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10518
Actions Inhibitor
CAS No. 404950-80-7
Formula C21H23N3O2
M. Wt 349.4
Purity >98%
Synonyms NVP-LBH589, LBH-589

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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