LBH589 (Panobinostat)

LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
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LBH589 10mg
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LBH589 50mg
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LBH589 100mg
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LBH589 200mg
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LBH589 (Panobinostat) 10mM * 1mL in DMSO
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Adooq Products cited in reputable paper
Adooq's LBH589 (Panobinostat) has been cited by 5 publications
  • Jalila Chagraoui, .et al. , Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
  • Gils Jose, .et al. , Cancers (Basel), 2020, Oct 31;12(11):E3211 PMID: 33142721
  • Shariful Islam, .et al. , Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
  • Giovanni Bocci, .et al. , ACS Pharmacol Transl Sci, 2020, Oct 14
  • Justin Kale, .et al. , EMBO Rep, 2018, Sep; 19(9): e45235 PMID: 29987135
  • Biological Activity
    Discription LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
    Target Value
    Product Information
    Catalog Num A10518
    Formula C21H23N3O2
    Molecular Weight 349.4
    CAS Number 404950-80-7
    Synonyms NVP-LBH589

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 60 mg/mL (171.7 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+48% PEG 300+2% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 28.62 mL 143.1 mL 286.2 mL
    0.5 mM 5.72 mL 28.62 mL 57.24 mL
    1 mM 2.86 mL 14.31 mL 28.62 mL
    5 mM 0.57 mL 2.86 mL 5.72 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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