Licofelone

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COX/LOX inhibitor

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Catalog No. A11697

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Licofelone 5mg A11697-5

Regular Price: $100.00

Special Price: $85.00

Licofelone 10mg A11697-10

Regular Price: $180.00

Special Price: $153.00

Licofelone 50mg A11697-50

Regular Price: $760.00

Special Price: $646.00

Licofelone 100mg A11697-100

Regular Price: $1,200.00

Special Price: $1,020.00

Licofelone 10mM * 1mL in DMSO A11697-10mM-D

Regular Price: $135.00

Special Price: $114.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both.

Licofelone

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Chemical Information

Catalog Num A11697
Actions Inhibitor
M. Wt 379.88
Formula C23H22ClNO2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 156897-06-2
Synonyms N/A
SMILES code CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C
Chemical Name [6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid

Biological Activity

Description
Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both.

Solubility

Solubility (25°C)* In vitro DMSO 76 mg/mL (200.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol 10 mg/mL (26.32 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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