Nilotinib (AMN-107)

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Bcr-Abl inhibitor

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Catalog No. A10644

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Nilotinib (AMN-107) 100mg A10644-100
$30.00
Nilotinib (AMN-107) 200mg A10644-200
$50.00
Nilotinib (AMN-107) 10mM * 1mL in DMSO A10644-10mM-D
$72.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.

Nilotinib (AMN-107)

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Chemical Information

Catalog Num A10644
Actions Inhibitor
M. Wt 529.5
Formula C28H22F3N7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 641571-10-0
Synonyms AMN107
SMILES code CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5
Chemical Name 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide

Biological Activity

Description
Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.
Targets
Bcr-Abl (Murine myeloid progenitor cells)
<30 nM

Solubility

Solubility (25°C) * In vitro DMSO 27 mg/mL (50.98 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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