Nilotinib (AMN-107)
Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.
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Adooq Products cited in reputable paper
Adooq's Nilotinib (AMN-107) has been cited by 2 publications
- Rami Shinnawi, .et al. , Stem Cell Reports, 2015, Oct 13; 5(4): 582-596 PMID: 26372632
- Tetsuya Saita, .et al. , Biol Pharm Bull. , 2015, 38(10):1652-7 PMID: 26424026
Biological Activity
| Description | Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM. | |||||
|---|---|---|---|---|---|---|
| Targets |
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| Cell Research |
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Product Information
| Catalog Num | A10644 |
|---|---|
| Formula | C28H22F3N7O |
| Molecular Weight | 529.5 |
| CAS Number | 641571-10-0 |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 26 mg/mL (49.09 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+30% PEG 300+5% Tween 80+ddH2O | 2 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.89 mL | 94.43 mL | 188.86 mL |
| 0.5 mM | 3.78 mL | 18.89 mL | 37.77 mL |
| 1 mM | 1.89 mL | 9.44 mL | 18.89 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
