NPI-2358 (Plinabulin)

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Microtubule Inhibitor

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Catalog No. A10654

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NPI-2358 5mg A10654-5
$60.00
NPI-2358 10mg A10654-10
$100.00
NPI-2358 50mg A10654-50
$300.00
NPI-2358 100mg A10654-100
$500.00
NPI-2358 (Plinabulin) 10mM * 1mL in DMSO A10654-10mM-D
$99.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells.

NPI-2358 (Plinabulin)

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Chemical Information

Catalog Num A10654
Actions Inhibitor
M. Wt 336.4
Formula C19H20N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 714272-27-2
Synonyms NPI2358
SMILES code CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2
Chemical Name (3E,6E)-3-benzylidene-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

Biological Activity

Description
NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells.
Targets
Tubulin
9.8 nM-18 nM

Solubility

Solubility (25°C)* In vitro DMSO 54 mg/mL heating (160.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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