Aurora A/B Kinase inhibitor

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Catalog No. A11171

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-03814735 5mg A11171-5

Regular Price: $90.00

Special Price: $72.00

PF-03814735 10mg A11171-10

Regular Price: $160.00

Special Price: $128.00

PF-03814735 50mg A11171-50

Regular Price: $600.00

Special Price: $480.00

PF-03814735 100mg A11171-100

Regular Price: $1,200.00

Special Price: $960.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.


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Chemical Information

Catalog Num A11171
Actions Inhibitor
M. Wt 474.48
Formula C23H25F3N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 942487-16-3
Synonyms PF03814735
SMILES code CC(=O)NCC(=O)N1[[email protected]]2CC[[email protected]@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F
Chemical Name N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide

Biological Activity

PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
Aurora A Aurora B FLT1 FAK TrkA
0.8 nM5 nM10 nM22 nM30 nM


Solubility (25°C) * In vitro DMSO 0.4 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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