PF-03814735

Aurora Kinase inhibitor

158 Customer Reviews
Catalog No. A11171

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-03814735 5mg A11171-5
$90.00
PF-03814735 10mg A11171-10
$160.00
PF-03814735 50mg A11171-50
$600.00
PF-03814735 100mg A11171-100
$1,200.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-03814735 is a novel, potent, orally bioavailable, reversible inhibitor of both Aurora1 and Aurora2 kinases. PF-03814735 produces a block in cytokinesis, resulting in inhibition of cell proliferation and the formation of polyploid multinucleated cells.

PF-03814735

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Chemical Information

Catalog Num A11171
Actions Inhibitor
M. Wt 474.48
Formula C23H25F3N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 942487-16-3
Synonyms PF03814735
SMILES code CC(=O)NCC(=O)N1[[email protected]]2CC[[email protected]@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F
Chemical Name N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide

Biological Activity

Description

PF-03814735 is a novel, potent, orally bioavailable, reversible inhibitor of both Aurora1 and Aurora2 kinases. PF-03814735 produces a block in cytokinesis, resulting in inhibition of cell proliferation and the formation of polyploid multinucleated cells.

Targets
Aurora A Aurora B FLT1 FAK TrkA
0.8 nM5 nM10 nM22 nM30 nM

Solubility

Solubility (25°C) * In vitro DMSO 0.4 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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