R935788 (Fostamatinib disodium, R788)

Syk Inhibitor

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Catalog No. A10771

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
R935788 5mg A10771-5

Regular Price: $90.00

Special Price: $72.00

R935788 10mg A10771-10

Regular Price: $150.00

Special Price: $120.00

R935788 50mg A10771-50

Regular Price: $430.00

Special Price: $344.00

R935788 100mg A10771-100

Regular Price: $750.00

Special Price: $600.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

R935788 (Fostamatinib disodium, R788)

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Chemical Information

Catalog Num A10771
Actions Inhibitor
M. Wt 624.4
Formula C23H24FN6O9P.2Na
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1025687-58-4
Synonyms R-935788, Fostamatinib disodium, R788
SMILES code CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]
Chemical Name (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate, disodium

Biological Activity

Description
R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
Targets
Syk (Cell-free assay)
41 nM

Solubility

Solubility (25°C) * In vitro DMSO 0.4 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80,pH6.5 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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