STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).
STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).
Cell Research
Cell Line
Type
Value
Description
References
Product Information
Catalog Num
A10866
Formula
C15H13N3S
Molecular Weight
267.4
CAS Number
315702-99-9
SMILES
CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
Synonyms
STF62247
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
47 mg/mL (175.8 mM)
Water
Insoluble
Ethanol
3 mg/mL (11.22 mM)
In vivo
1% DMSO+30% polyethylene glycol+1% Tween 80
6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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